Patterns of Cerebellar Gray Matter Atrophy Across Alzheimer’s Disease Progression
نویسندگان
چکیده
منابع مشابه
Gray matter atrophy rate as a marker of disease progression in AD
Global gray matter (GM) atrophy rates were quantified from magnetic resonance imaging (MRI) over 6- and 12-month intervals in 37 patients with Alzheimer's disease (AD) and 19 controls using: (1) nonlinear registration and integration of Jacobian values, and (2) segmentation and subtraction of serial GM volumes. Sample sizes required to power treatment trials using global GM atrophy rate as an o...
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Huntington disease (HD) is caused by an abnormally expanded cytosine-adenine-guanine (CAG) trinucleotide repeat in the HTT gene. Age and CAG-expansion number are related to age at diagnosis and can be used to index disease progression. However, observed onset-age variability suggests that other factors also modulate progression. Indexing prodromal (pre-diagnosis) progression may highlight thera...
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34 Courtney Oare is a 2017 graduate of Purdue University who majored in Radiological Health Sciences with a concentration in Medical Physics. In the School of Health Sciences Honors Program, she partook in research for three years with an interest in imaging and evaluation of disease. Outside of coursework and research, she served as an Ambassador for the College of Health and Human Sciences, w...
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Gray matter atrophy has been shown to be a strong correlate to clinical disability in multiple sclerosis (MS) and its most commonly used animal model, experimental autoimmune encephalomyelitis (EAE). However, the relationship between gray mater atrophy and the spinal cord pathology often observed in EAE has never been established. Here EAE was induced in Thy1.1-YFP mice and their brains imaged ...
متن کاملGray Matter Atrophy Associated With Motor Dysfunction
34 Courtney Oare is a 2017 graduate of Purdue University who majored in Radiological Health Sciences with a concentration in Medical Physics. In the School of Health Sciences Honors Program, she partook in research for three years with an interest in imaging and evaluation of disease. Outside of coursework and research, she served as an Ambassador for the College of Health and Human Sciences, w...
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ژورنال
عنوان ژورنال: Frontiers in Cellular Neuroscience
سال: 2018
ISSN: 1662-5102
DOI: 10.3389/fncel.2018.00430